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Tirzepatide, the active ingredient in Mounjaro, activates both GLP-1 and GIP receptors in the body, leading to significant weight loss and metabolic changes

In contrast, weight loss outcomes were similar when the researchers compared participants by age, race, ethnicity, initial body mass index, and initial HbA1c level

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KW-6356 is a second-generation A2A antagonist which has shown positive results with regard to motor progression in early-stage PD, as assessed by changes in the MDS-UPDRS motor score from baseline until the end of follow-up, both in combination with levodopa (NCT03703570) and as monotherapy (NCT02939391, Table 2) (Chen et al