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And further studies of physiological and brain activity showed that BRP activates metabolic and neuronal pathways separate from those activated by GLP-1 or semaglutide

This may result from altered gut motility or changes in intestinal fluid secretion

Talk to your healthcare provider first Reach out to your healthcare provider before stopping or weaning off semaglutide

Always verify your specific insurance formulary, as coverage varies widely

The first animal studies showing that GLP-1 potentially had effects on the CV system was published in 2002, and the first study to show cardioprotection was in 2008 (102, 211), but it was not until the LEADER cardiovascular outcomes trial (CVOT) with liraglutide, published in 2016, that a reduction in CV risk with a GLP-1RA was documented (100)