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2 Oral microbiota, dysbiosis and pathogenesis of HNCs The oral cavity represents one of the most complex microbiomes in the human body (54), providing support and resources for an impressive number of microbial species (from 700-750 to several thousands) (28, 29), which include bacteria, archaea, fungi and protozoa (55), from at least 12 phyla (28), such as Actinobacteria , Bacteroidetes , Firmicutes , Proteobacteria , Spirochaetes , Synergistetes and Tenericutes (28)