Around 30% of patients start with bulbar symptoms, which affect the muscles used for speaking and swallowing, leading to problems like slurred speech (dysarthria), trouble swallowing (dysphagia), and twitching of the tongue muscles (Chi et al., 2013)
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The proportion of patients who discontinued for lack of glycemic control or who were rescued for meeting prespecified glycemic criteria was 15% in the saxagliptin 2.5 mg add-on to metformin HCl group, 13% in the saxagliptin 5 mg add-on to metformin HCl group, and 27% in the placebo add-on to metformin HCl group
According to previous studies, LD growth depends on lipid synthesis genes such as DGAT2 and GPAT4, and the key to the growth of LDs is the recruitment of DGAT2 and GPAT4 to the LD surface 18
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