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43 During chronic infection, HBV-specific T lymphocytes are prone to apoptosis, with significantly reduced ability to secrete cytokines and proliferate, resulting in exhausted function, which may be one of the mechanisms leading to persistent HBV infection

Cohort participants contributed time at risk from January 1 st 1998 until the outcome of interest, death, or end of follow up at December 31 st 2021, whichever occurred first

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