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When looking at the endogenous NAD + fluxes at the systemic level, most organs do not synthesize NAD + de novo, but can utilize NAM made in the liver 39

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This reaction is catalyzed by the enzyme gamma-glutamyl-cysteine synthetase, which is encoded by the gene gshA

The hippocampus has long been a pivotal focus in epilepsy research and observations have shown a reduction in the size of hippocampi in epileptic patients brains (Pitknen and Sutula, 2002)