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The fact that the additives lead to more TPM is, itself, an important indicator of increased toxicity because the TPM in cigarette smoke leads to substantial increases in risk of cardiovascular disease, with a steep and highly nonlinear dose-response at low levels of exposure [123][126]

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The gentler throat hit enables higher absorption than freebase without the harshness, mimicking the nicotine delivery of traditional cigarettes more closely

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GIAMBRI: I remember that I wrote a poem about my mom, and I had my big cardboard box full of my archives of all those poems since I was like 17 years old