Blood sugar increase: HbA1c rises, often returning toward pre-treatment levels
Its physiological actions, such as increasing insulin secretion, enhancing satiety, and slowing gastric emptying, contribute to lowering HbA1c levels and promoting weight loss
doi: 10.1001/jama.2021.3224 23
Clinical trials show superior weight loss outcomes compared to tirzepatide alone, though the combination significantly increases gastrointestinal side effects like nausea and vomiting
Alternatives to GLP-1RAs If you or your doctor are concerned about this potential risk, there are other classes of medications for managing Type 2 diabetes: SGLT2 inhibitors (e.g., Jardiance, Farxiga) DPP-4 inhibitors (e.g., Januvia) Metformin (still the gold standard) Insulin therapy Lifestyle interventions like medically supervised weight loss programs Each comes with its own risk/benefit profile, so its not about finding a perfect drugits about finding the right one for your personal health profile