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The -3 pathway produces anti-inflammatory mediators such as eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) (42), while the -6 pathway generates arachidonic acid-derived pro-inflammatory mediators, which in turn modulate inflammatory states (43), and their -6 to -3 ratio is typically imbalanced, which may exacerbate inflammatory responses (44)

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The net effect of this release is to slow the digestion process, which introduces less glucose (blood sugar) into your bloodstream, as well as to trigger feelings of satiety (fullness, satisfaction)

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Rieger, Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis