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To address the functional importance of tirzepatide at each incretin receptor, we investigated the effect of loss-of-function approaches on insulin secretion in mice

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One-carbon metabolism refers to biochemical pathways involving the transfer of single carbon units and is critical for the synthesis of proteins and nucleotides, amino acid homeostasis, and epigenetic control of DNA expression

NB: Involvement of DPP-8 and DPP-9 in diabetes and obesity, if any, is not well understood at this time (Han et al., 2015)