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Biological activity of the endocannabinoid system Once in the body, 9 -THC and CBD exert their effects via the endocannabinoid system (ECS).The identification of the specific binding sites for 9 -THC in the brain [45], complemented by the cloning of the cannabinoid receptor 1 (CB1), that led to the development of the concept of a cannabinoid receptor system given the binding of 9 -THC to CB1 as a partial agonist [46]

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Beyond their friendship, Schwartz and Sinatra shared numerous business ventures including thoroughbred ownership and philanthropic projects such as the Barbara Sinatra's Children's Center