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While nicotine acts as a stimulant in the central and peripheral nervous system of people and other mammals, it obstructs oxygen delivery by narrowing blood vessels throughout the body, including the ones in the umbilical cord

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The warnings and precautions sections of the drugs prescribing information have been updated, and FDA recommends that (1) patients tell their health care providers about any history of psychiatric illness before starting varenicline and (2) clinicians and patients monitor for changes in mood and behavior during treatment with varenicline

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