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98 Casearia sylvestris essential oil showed a selective cytotoxic effect against human cervix carcinoma cell line (HeLa), human lung cancer cells (A-549), and human colon adenocarcinoma cells (HT-29) at 63.3, 60.7 and 90.6 g/mL respectively

p = 0.063), also with high heterogeneity (I 2 = 87%)

This approval represents the first FDA-approved drug specifically targeting mitochondrial function, establishing regulatory precedent for the mitochondrial dysfunction pathway in aging and neurodegeneration

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IU and dosing math for researchers U100 insulin syringes calibrate volume in international units where 100 IU equals 1 mL, so 1 IU equals 0.01 mL