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This synergy occurs because each agent targets different cancer pathways, helping to reduce resistance

RC-fed Dpp4 / mice exhibited no detectable plasma DPP4 activity, an approximately 8-fold increase in plasma active GLP-1, reduced fasting glucose, improved glucose tolerance, and no difference in body weight compared with Dpp4 +/+ mice (Figure 2A and Supplemental Figure 1, A and B

Yu CT, Wu JK, Chang CC, Chen CL, Wei JC

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