Caregivers may not always be available to assist with injections
Histopathological changes and oxidative stress might also co-occur or be interlinked bidirectionally
In a HA- hydrogel containing resveratrol-loaded (10 mg) chitosan (CS) nanoparticles, release of resveratrol was observed, and it counteracted oxidative damage that was induced by ROS generation in a TNF-/IFN--treated (AD-like) human keratinocytes, without induction of cell death [191]
Ren JJ, Yuan XW, Zhang YH, Meng ZL, Liang XW, Kim NH, Li YH Diosmetin Delays In Vitro Aging of Porcine Oocytes by Improving Mitochondrial Function and Reducing Oxidative Stress
Brain Pathol 26:227236 Zhou J, Li A, Li X, Yi J (2019) Dysregulated mitochondrial Ca 2+ and ROS signaling in skeletal muscle of ALS mouse model