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This activation triggers intracellular signaling cascades including the extracellular signal-regulated kinase (ERK) pathway, which increases expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF)

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Hidden Costs Factor in additional expenses: Rolling papers: $2-$5 for 100 leaves Filters: $3-$8 for 200 filters Rolling machine: $5-$30 one-time purchase Storage containers: $5-$15 to keep tobacco fresh Time investment: 5-10 minutes per session to prep and roll Even accounting for these costs, the savings remain significant