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Samples from isogenic breast cancer lines expressing mutant p53 (T47D), and different levels of MDM2 (MDM2 knockdown) were analyzed for expression levels in different cellular compartments and for MDM2/PARN interaction using cell fractionation and co-immunoprecipitation, respectively, followed by western blot

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Reduced-Risk Nicotine Products and the Continuum of Risk The most consequential current debate in tobacco tax policy concerns how to treat non-combustible nicotine products: e-cigarettes, nicotine pouches, heated tobacco products, and snus