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The NIH Office of Dietary Supplements and the American Academy of Family Physicians identify the following groups as most vulnerable: Adults over 50 Age-related decline in stomach acid production reduces the ability to release B12 from food proteins

In the United States, between 3 to 6 % of the population are vitamin B12 deficient and up to 20% have marginally depleted levels (3)

Dilute solutions (2.5 mg/mL) need larger volumes, making precise measurements easier but requiring more storage space

However, chronic or excessive inflammation shifts the balance toward tissue destruction