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If you'd prefer not to start at maximum strength, use this guide based on your previous smoking habits: I smoke fewer than 10 cigarettes per day: 6 - 10mg I smoke between 10 & 20 cigarettes per day: 11 - 15mg I smoke 20 or more cigarettes per day: 20mg Many users then choose to gradually reduce their chosen nicotine strength over time in 3-5mg intervals

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The expression of the 5HT1A and 5HT2 receptors, as well as the serotonin transporter, has changed, as well as disturbances in adenylyl cyclase activity and the serotonin signaling molecules downstream, are related with nicotine use [77]

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