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1.4 Review Planning, Scope, and Review Questions Addressing the scope of the review and identifying important questions are necessary before any meaningful review can begin, as they can affect the key areas specified in the systematic review protocol

One of the main problems with the original study lies in the sample of people it used it was exclusively male, with the estimate of mortality in particular only based on data from British male doctors

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J Cell Biol (2007) 179:i166