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4 Specific role of mitochondrial energy metabolic reprogramming in AKI During AKI, metabolic reprogramming in TECs may temporarily compensate for deficits in energy supply, support cellular survival, and partially mitigate tissue damage, thereby facilitating early repair processes

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The GR signaling pathway associated with carriage of the G allele of the rs2270777 CDK4 SNP showing increased GR co-regulator activity (e.g., NCOA3 , DRIP205 , SMARCA4 and CBP increased expression +1.2-fold) (Table 4, Supplementary Figure S3)