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Methylation connects with glutathione through homocysteine and the transsulfuration pathway, which can provide cysteine for glutathione synthesis

Glutamine-derived -ketoglutarate can fuel fatty acids synthesis through the reductive carboxylation mediated by isocitrate dehydrogenase (IDH)

4a, the G/D-CuP group exhibited the most intense CD206-associated red fluorescence signal among all treatment groups, indicating that G/D-CuP promotes macrophage polarization toward the M2 phenotype

Van Gaal, L.F

** In subjects with severely impaired renal function or on dialysis, chronic oral administration of L-carnitine may cause accumulation of TMA and TMAO in the blood resulting in trimethylaminuria, a pathological condition characterized by a strong "fishy odor" present in the urine, breath and sweat of the patient