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However, in Vitis flexuosa different GTSs may play diverse roles in pathogen defense, since only one out of five characterized GST genes was induced, while expression of the other GSTs was down-regulated following infection by the necrotrophic fungi B

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Their neglect has often resulted from early adverse events attributable to poor pharmacokinetic design, incomplete receptor mapping, or the absence of enabling technologies now considered routine, such as long-acting peptide conjugation, tissue-selective targeting, and signal-bias optimization