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Akiyama Y, Nomiya A, Niimi A et al: Botulinum toxin type a injection for refractory interstitial cystitis: A randomized comparative study and predictors of treatment response

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The clamp domain starts to swing down during strand separation, prompting the TFIIF arm domain to come closer to the TFIIB B-linker and Pol II rudder, thereby forming a physical barrier for DNA re-annealing

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