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Emerging therapeutic strategies aim to target these pathways specifically like MATs, NOX inhibitors, and Nrf2 activators, though clinical success has been limited by off-target effects and the dual role of ROS in physiological signaling (Pergola et al., 2021)

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Comp Biochem Physiol B Biochem Mol Biol 134:265270 Huang JW, Tian LX, Du ZY (2005) Pyridoxine deficiency of grouper, Epinephelus coioides physiological and biochemical alteration