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Thus, p62 competes with Nrf2 for Keap1 binding at the bottom of the DC domain, dislocating Nrf2 from Keap1 and leading to the accumulation of Nrf2 (Figure 1) ( Keap1-independent Mechanism of Nrf2 Regulation Although the majority of Nrf2 is mainly moderated by Keap1 in answer to ROS/electrophiles, some researchers found that the PI3K-AKT signaling pathway could also stimulate Nrf2 (Figure 1) (Salazar et al., 2006)

Epub 2005 Feb 17

Drug Interactions: Patients who have been treated with MAO inhibitors within two to three weeks prior to the administration of dopamine HCl should receive initial doses of 1/10th normal Tricyclic antidepressants may potentiate the pressor response to adrenergic agents Cardiac effects of dopamine are antagonized by beta-adrenergic blocking agents Haloperidol and haloperidol-like drugs suppress the dopaminergic renal and mesenteric vasodilation induced at low rates of dopamine infusion References: Biaggioni I (2024): Adrenoceptor Agonists & Sympathomimetic Drugs (Chapter 9)

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