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These cytokines typically associate with immunoglobulin E production, eosinophilia, mast cell activation, and mucus secretion by airway epithelial cells 1

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Made of edible green leaves, food-grade ingredients, and pharmaceutical-grade nicotine, this straight tobacco alternative contains the same nicotine content as traditional tobacco chew. There is approximately 7.5 mg of total nicotine per gram of product, measured on a wet-weight basis, and a net weight of 1.2 oz. (34.02 g) per can