tobacco related cancers carcinogens, their biomarkers and tobacco-induced cancer Smokeless tobacco and cigarette smoking:

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For an example of biomonitoring, tobacco smoking and the levels of cotinine showed association with a pronounced (about 50%) reduction in fecundability, resulting in a longer time-to-pregnancy 26 , because their developmental processes amplify or magnify the toxic responses via epigenetic or cell memory 27

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A typical cigarette contains less than 1 gram of tobacco