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Rapid enzymatic degradation limited oral bioavailability, short plasma half-lives, and pleiotropic signaling profiles confined peptides largely to hormone replacement therapies or niche endocrine indications

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10.1016/j.ebiom.2021.103617 [DOI] [PMC free article] [PubMed] [Google Scholar] 35.Hernandez A, Martinez ME, Ng L, Forrest D (2021) Thyroid hormone deiodinases: dynamic switches in developmental transitions

These typically resolve as your body adjusts to the medication, but they can be disruptive during the first one to two weeks at each new dose level

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