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Guerreiro S, Ponceau A, Toulorge D, et al

Large hydrophilic chelators, such as DFO (a highly polar molecule with a molecular weight of 560 Da), exhibit poor BBB permeability when administered intravenously, remaining in the circulation and extracellular space, while only minimal amounts can cross into the brain parenchyma

Interestingly, the additional data source does not seem to similarly improve performance in the GSH term models, with performance of transcriptomics-only GSH term classifiers comparable to classifiers using both transcriptomic and metabolomic features (Fig

Safety, pharmacokinetics and pharmacodynamics of the anti-hepcidin Spiegelmer lexaptepid pegol in healthy subjects