Potential confounders included sex, age, race/ethnicity, education, household income, body mass index (BMI) (a measure of body fat based on weight and height), disease status, overall tobacco use, marijuana use, and secondhand smoke exposure
The actual number is skewed by very high prices in a handful of countries like Australia and New Zealand and very low prices in parts of Africa and Asia
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If buying a block from an online source, ensure it has been appropriately cured and dried before using it
In shamanic rituals the potent Nicotiana rustica can even be psychotropic itself, plunging a person into a catatonic state where they move between worlds