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This is in agreement with studies where nicotine decreased PG synthesis in the vascular endothelium via an increase in oxidative stress 36,37,38

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Data availability All the data in the present analysis is available at NHANES website Abbreviations NHANES: National Health and Nutrition Examination Survey TST: testosterone EST: estrogens SHBG: sex hormone-binding globulin CDC: Centers for Disease Control and Prevention NCHS: National Center for Health Statistics ID-HPLC-APCI-MS/MS: isotope-dilution high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometric LLOD: lower limit of detection ID-LC-MS/MS: isotope dilution liquid chromatography tandem mass spectrometry BMI: body mass index RCS: restricted cubic spline SD: standard deviation References GBD 2019 Diseases and Injuries Collaborators

HVAC systems carry smoke through an entire unit, and if you have older vents or duct systems, the smell can keep circulating through rooms that were never directly exposed