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Metabolic: Hyperglycemia advanced glycation end-products (AGEs), polyol pathway activation, oxidative stress, mitochondrial dysfunction nerve ischemia and axon loss in diabetic neuropathy per ADA Standards of Care

Oxidative stress is essentially the damage that is done to the body when the amount of free radicals is higher than the number of antioxidants being produced by the body

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The elongation phase of fatty acid synthesis starts with the formation of acetyl-ACP and malonyl-ACP by acetyl transacylase and malonyl transacylase catalyzing the reactions: Once acetyl-ACP and malonyl-ACP are formed, fatty acids are synthesized by the repetition of the following reaction sequence: condensation reduction dehydration reduction (Fig