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The nicotine found in NRT is not addictive and does not cause cancer since it produces a lower level of nicotine in the blood than smoking a pack of cigarettes daily

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

Microorganisms and endotoxin cross the intestinal mucosal barrier into the blood and induce endotoxemia, subsequently leading to injury to the liver and other organs, intestinal inflammation, and rectal carcinogenesis (Elamin et al., 2013)

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