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Interferons are cytokines that are naturally produced in the body in response to immune stimulation, viral infections, and other chemical stimulation ( in vivo response to IFN- has been observed in MS patients with neutralizing antibodies against interferon-beta and that IFN-2a reduces MRI disease activity in relapsing-remitting multiple sclerosis (RRMS) ( Mechanistically, type I interferons signal through interferon alpha/beta receptor-1 (IFNAR1) and interferon alpha/beta receptor-2 (IFNAR2), leading to activation of tyrosine kinase 2 (Tyk2) and janus kinase-1 (JAK1), signal transducer and activated transcription-1 (STAT1) and signal transducer and activated transcription-1 (STAT2) phosphorylation cascades, and ultimately activation of hundreds of genes important in IFN mediated immune and antiproliferative functions ( Both immune cells and tumor cells can produce interferons in a complex interplay

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W J Gastroenterol 21:993996 Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar KT, Senthil kumar M, Ganesh Malay Chatterjee GNK (2011) A review of metallothionein isoforms and their role in pathophysiology