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This is one part of Virchows Triad, a group of three conditions that increase the risk of clotting, and it can occur during prolonged periods of immobility, such as extended travel or sedentary work

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Studies have confirmed that cigarette extracts induce the conversion of macrophages to osteoclasts through the classic RANKL-RANK pathway, upregulate the expression of NFATc1, promote macrophage activation, and induce the expression of the osteoclastogenesis-related proteases TRAP, cathepsin K and MMP-9 (129131)

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Who knew something so small could make such a big impact