Originally described by Otto Warburg in the 1920s, this metabolic reprogramming allows cancer cells to meet their bioenergetic and biosynthetic demands through aerobic glycolysis, generating ATP rapidly and producing metabolic intermediates essential for cell proliferation ( PGC-1 and TFAM , as well as those encoding components of the electron transport chain
PubMed, Verhoef, Petra, and Lisette C
We showed that, unlike other conventional anti-cancer agents, 5-fluorouracil (5-FU) or cytosine arabinoside (ara-C), which are uracil and cytidine analogs, JMF4073 is not toxic to untransformed myeloid cells
doi:10.1055/s-2007-1014295
Direct IGF-1 administration carries more pronounced metabolic effects than GH-secretagogue routes and is more strictly regulated