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5 Recent mechanism studies implicated that the tumor microenvironment, in particular, tumor-associated macrophages (TAMs) constitute approximately 50% of cells in BC bulk, had a pivotal role in tumor progression and metastasis of BC

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Dysregulation of these pathways through chronic exposure to cigarette smoke or nicotine may therefore impair immune homeostasis and promote persistent inflammatory signaling, further contributing to immunosenescence-like patterns in people with MS

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