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Electrophysiological recordings demonstrate that Dihexa-treated neurons exhibit significantly increased frequency of miniature excitatory postsynaptic currents (mEPSCs), indicating enhanced synaptic transmission

10.1074/jbc.M506096200 241 ScambiC.De FranceschiL.GuariniP.PoliF.SicilianoA.PattiniP.et al (2009)

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This broader receptor profile produces effects across pigmentation, sexual response, and appetite-regulation pathways making patient selection and protocol design particularly important