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In addition, the UBX7-p97-UFD1/NPL4 complex, consisting of a ubiquitin-targeted ATP-dependent segregase, p97, and two heterodimeric cofactors, UBX7 and UFD1/NPL4, extracts ubiquitinated NRF2 from the KEAP1-NRF2 complex and transfers it to the 26S proteasome for its degradation [154] (Fig
Studies have indicated that the overexpression of SNRPD1 may promote cancer cell proliferation and survival by regulating key biological processes such as RNA splicing, cell cycle progression, and DNA replication
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