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This group of abnormalities comprised the three enzymatic defects in the synthesis of creatine:arginine:glycine amidinotransferase (AGAT) deficiency (OMIM 612718), guanidinoacetate methyltransferase (GAMT) deficiency (OMIM 612736), and SLC6A8 deficiency (OMIM 300352)

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Access this article Similar content being viewed by others Abbreviations APX: Ascorbate peroxidase CAGE: Cap analysis of gene expression CAT: Catalase DEG: Differentially expressed gene DEM: Differentially expressed metabolite DEP: Differentially expressed proteins DHAR: Dehydroascorbate reductase DIGE: Differential gel electrophoresis GSH: Glutathione GSHS: Glutathione synthetase GSSG: Glutathione disulfide GS: Glutathione synthase GST: Glutathione S -transferase GPx: Glutathione peroxidase GT: Glutathione transferase GRx: Glutaredoxin iTRAQ: Isobaric tag for relative and absolute quantitation MDHAR: Monodehydroascorbate reductase MPSS: Massively parallel signature sequencing MudPIT: Multidimensional protein identification technology PAH: Polycyclic aromatic hydrocarbon PRX: Peroxiredoxins ROS: Reactive oxygen species SAGE: Serial analysis of gene expression SCCs: Suspension culture cells SOD: Superoxide dismutase -ECS: -Glutamyl-cysteine synthetase References Akbar S, Wei Y, Yuan Y et al (2020) Gene expression profiling of reactive oxygen species (ROS) and antioxidant defense system following Sugarcane mosaic virus (SCMV) infection

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