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Mechanistically, we showed that system x C blockade in conjunction with APR-246, synergistically depleted intracellular GSH, resulting in mitochondrial ROS accumulation, lipid peroxidation and ultimately apoptotic cell death (Fig

doi: 10.1128/MCB.00467-19

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In some embodiments, the otic formulation or composition comprises about 8% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

The field is young, but ALS patients might one day receive personalized microbiome-based adjuncts for example, a consortium of bacteria tailored to produce neuroprotective metabolites or to reduce neurotoxic ones as part of a broader therapeutic regimen