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294 Cellular and animal experiments have found that long-chain fatty acids cause excessive oxidation of adipocytes, producing inflammatory cytokines, facilitating macrophage infiltration, and leading to systemic low-grade inflammation

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Manhas A, Lone MY, Jha PC (2019) In search of the representative pharmacophore hypotheses of the enzymatic proteome of Plasmodium falciparum : a multicomplex-based approach

Supporting this hypothesis, studies have demonstrated that in individuals with increased intestinal permeability, opioid peptides derived from gluten and casein can enter systemic circulation and potentially enhance opioid activity in the brain (Cass et al

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