indian tobacco tree (Lobelia inflata) [Campanulaceae] Stem & Leaves This Virginian type has good uniformity producing dark cigar and pipe tobacco. Nicotiana glauca - Wikipedia

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The process, Breaux says, is not unlike the one he first used with absinthe, in evaluating the toxicity of wormwood and finding ways to eliminate such risks while still utilizing the plant in a distilled spirit

JSTOR 3111987

They sit in a different part of the flavor and draw spectrum and are worth trying if you have sampled something else and found it either too harsh or too weak

Region with the most smokers: Southeastern states have the highest concentration overall, but at the city level, Midwestern cities in Ohio, Michigan, and Indiana dominate the rankings