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The resulting increase in GH activity promotes lipolysis particularly visceral adipose tissue (VAT) reduction without directly influencing appetite or insulin secretion in the same manner as incretin-based therapies

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Pre trial oral antidiabetes agents were continued as background therapy except for DPP 4 inhibitors or thiazolidinediones in both treatment arms

Slower gastric emptying could affect how quickly amitriptyline is absorbed, though it shouldnt change the total amount absorbed