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(42) found that HDACi (0.2 M MS-275, 1.5 mM Valproic acid) increased H3/H4 acetylation levels by inhibiting histone deacetylase activity, interfering with chromatin openness and DNA repair complex recruitment, thereby significantly inhibiting B cell CSR and reducing the expression of IgG subclasses (IgG1, IgG2a) and IgA