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Furthermore, evidence indicates that GLP-1RAs inhibit inflammation in fibroblast-like synoviocytes (FLS) and attenuate RA progression [18], suggesting their potential therapeutic utility in rheumatic disorders [19]

Discussion Through extensive small-molecule screening, biochemical assays and X-ray crystallography, we have identified several potent GSTO1 inhibitors

The major plant pathway is different from the animal l-ascorbate synthesis pathway that involves 10 enzymatic steps from d-glucose to l-ascorbate via the intermediate formation of GDP-d-mannose and l-galactose [3] (Figure 1a)

Int J Basic Clin Pharmacol

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