In primary cortical neurons subjected to OGD/R, Vitexin enhanced Nrf2 nuclear translocation by regulating Keap1, upregulated HO-1, GPX4, and SLC7A11, and reduced TFR1 expression (Guo and Shi, 2023)
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However, accumulating ChIP-seq data indicates that NRF2 predominantly binds intronic or distal intergenic regions (Malhotra et al, 2010
And understanding that gap determines whether an accidentally exposed vial gets discarded or simply returned to proper storage