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In humans, fasting systemic plasma concentrations of total GLP-1 (including metabolites generated by DPP-4-mediated degradation) are typically in the range of 510 pmol/L and can increase up to 40 pmol/L in response to a meal [236]

The peptide is produced in the lower small intestine after eating, stimulating insulin release

Although considerably smaller than the 34000Da peptide drugs, these small molecules are still around 700Da molecular weight further adding to computational modelling complexity

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