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the agency cited concerns over potential immune reactions, manufacturing impurities, and a lack of human safety data

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FIGURE 1 2 Literature search strategy To support the narrative synthesis, a focused literature search was conducted across PubMed, Web of Science, ScienceDirect, and SpringerLink, targeting English-language, peer-reviewed articles published between 2010 and 2025

No peer-reviewed human clinical trials for 5-Amino-1MQ have been published to date

Moreover, reducing drug dosage still achieved significant cytotoxic effects